Farideh Amirrad


Farideh Amirrad, Ph.D.

Postdoctoral Fellow

Chapman University

9401, Jeronimo Road, Irvine, CA, 92618



  • Ph.D. in Pharmaceutical Sciences, School of Pharmacy, Chapman University, CA, USA
  •  Master of Science in Pharmaceutical Sciences, School of Pharmacy, Chapman University, CA, USA
  • Doctor of Medicine, Medical University of Belgrade- Serbia

Research Interest:

  • Studying the effect of PKD gene mutation on cardiac structure and function in  PKD mouse model and human heart samples using in vivo, ex-vivo, and in vitro methods.
  • Examining the effect of PGRMC2 gene mutation on heart function and structure in a mouse model using in vivo, ex-vivo, and in vitro methods.
  • Studying the effect of hypoxia on PGRMC2 mouse model hearts using the hypoxic chamber.


  • Farideh Amirrad, Muhammad Imran Sajid, Francisco J. Nunez, Moom Rahman Roosan, Tom Vojtko, Scott McCulloch, Amal Alachkar, and Surya M. Nauli. Untargeted Metabolomics Analysis on Kidney Tissues from Mice reveals Potential Hypoxia Biomarkers. (Under Publication)
  • Amirrad F, Fishbein GA, Edwards RA, Nauli SM. Hypertrophic and fibrotic human PKD hearts are associated with macrophage infiltration and abnormal TGF-β1 signaling. Cell Tissue Res. 2022 Nov 15. doi: 10.1007/s00441-022-03704-y. Epub ahead of print. PMID: 36376769.
  • Nam YW, Pala R, El-Sayed NS, Larin-Henriquez D, Amirrad F, Yang G, Rahman MA, Orfali R, Downey M, Parang K, Nauli SM, Zhang M. Subtype-Selective Positive Modulation of KCa2.3 Channels Increases Cilia Length. ACS Chem Biol. 2022 Aug 19;17(8):2344-2354. doi: 10.1021/acschembio.2c00469. PMCID: PMC9396613.
  • Amirrad F, Pala R, Shamloo K, Muntean BS, Nauli SM. Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions. Front Cardiovasc Med. 2021 Nov 26;8:772961. doi: 10.3389/fcvm.2021.772961. PMID: 34901233.
  •  Amirrad F, Pytak PA, Sadeghiani-Pelar N, Nguyen JPT, Cauble EL, Jones AC, Bisoffi M. Prostate field cancerization and exosomes: Association between CD9, early growth response 1 and fatty acid synthase. Int J Oncol. 2020 Apr;56(4):957-968. doi: 10.3892/ijo.2020.4980. Epub 2020 Feb 10. PMID: 32319557.
  • DuBois BN, Amirrad F, Mehvar R. A Comparison of Calcium Aggregation and Ultracentrifugation Methods for the Preparation of Rat Brain Microsomes for Drug Metabolism Studies. Pharmacology. 2021;106(11-12):687-692. doi: 10.1159/000519667. Epub 2021 Oct 18. PMID: 34662883.
  • DuBois BN, Amirrad F, Mehvar R. Kinetics of dextromethorphan-O-demethylase activity and distribution of CYP2D in four commonly-used subcellular fractions of rat brain. Xenobiotica. 2019 Oct;49(10):1133-1142. doi: 10.1080/00498254.2018.1539782. Epub 2019 Jan 7. PMID: 30392427.
  • Bousoik E, Nabiee R, Amirrad F, Nichols A, Witt R, Mahdipoor P, Montazeri Aliabadi H. Heterogeneity and Plasticity of Human Breast Cancer Cells in Response to Molecularly-Targeted Drugs. Front Oncol. 2019 Oct 15;9:1070. doi: 10.3389/fonc.2019.01070. PMID: 31681603; PMCID: PMC6803545.
  • Mozaffari S, Bousoik E, Amirrad F, Lamboy R, Coyle M, Hall R, Alasmari A, Mahdipoor P, Parang K, Montazeri Aliabadi H. Amphiphilic Peptides for Efficient siRNA Delivery. Polymers (Basel). 2019 Apr 17;11(4):703. doi: 10.3390/polym11040703. PMID: 30999603.
  • Amirrad F, Bousoik E, Shamloo K, Al-Shiyab H, Nguyen VV, Montazeri Aliabadi H. Alzheimer’s Disease: Dawn of a New Era? J Pharm Pharm Sci. 2017;20(0):184-225. doi: 10.18433/J3VS8P. PMID: 28719360.

    Evaluation of cardiac function in vivo and ex vivo  using MRI, echocardiography, and isolated working heart system in mouse model: