Ayan Kumar Barui

CONTACT

Ayan Kumar Barui, PhD, MRSC
Postdoctoral Fellow
School of Pharmacy, Chapman University
Harry and Diane Rinker Health Science Campus
9401 Jeronimo Road, Irvine, CA 92618, USA
Mob: +1-714-516-5462

LinkedIn | Google Scholar

RESEARCH PROFILE

A research professional with 10+ years of total experience which comprises of 5+ years in PhD research and 4+ years in post – PhD research (postdoctoral and industrial experience) with an expertise in leading research and development in the field of chemistry and biotechnology through effectively managing collaborative nanomedicine projects (therapeutics for vascular diseases, cancers and bio-imaging). Demonstrated an excellence in leading activities pertaining to laboratory management, mentoring young researchers, manuscript writing, preparation of research grant application and conference presentation as evidenced by 43 peer – reviewed international publications (research article, review, editorial and book chapter) and several international conference awards during doctoral and postdoctoral research journey. Recognized as an Invited Reviewer for various international journals including Acta Biomaterialia, Nanoscale, Biomaterials Science, Journal of Materials Chemistry B, Materials Science and Engineering C etc, Editorial Board Member for BMC Cancer (Springer Nature), Topic Editor for MDPI Journals (Cancers, Pharmaceutics, Nanomaterials, Journal of Clinical Medicine and Biomedicines) as well as Member (MRSC) of the prestigious Royal Society of Chemistry (RSC), UK and American Heart Association (AHA), USA.

RESEARCH INTERESTS

  • Synthesis and characterization of different metal nanoparticles for diverse biomedical applications.
  • Investigation of underlying cause of ciliopathies and development of their treatment strategies.
  • Development of nanoparticles – based targeted drug delivery system for the treatment of vascular diseases and cancers.
  • Therapeutic applications of pro – angiogenic nanomaterials for ischemic diseases through nanomedicine approach.
  • Bio – imaging applications of different materials.

CAREER TIMELINE

  • Postdoctoral Fellow in Pharmaceutical and Biomedical Sciences, School of Pharmacy, Chapman University, California, USA | Nov 2021 – Present
  • Specialist (Visiting Scholar) in School of Pharmacy & Pharmaceutical Sciences, University of California Irvine (UCI), California, USA | Nov 2022 – Present
  • Associate Principal Scientist in Patanjali Research Institute (PRI), Haridwar, India | Aug 2020 – Dec 2020
  • Postdoctoral Research Associate in Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea | Jan 2018 – Mar 2020

ACADEMIC DETAILS

  • Doctor of Philosophy (PhD) in Nanobiotechnology from CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India | Jan 2012 – Jun 2017.
  • Master of Science (MSc) in Chemistry (Organic Chemistry specialization) with First Class (Scored 80.25%) from The University of Burdwan, Burdwan, India in 2011.
  • Bachelor of Science (BSc) with Honors in Chemistry with First Class (Scored 72.75%) from The University of Burdwan, Burdwan, India in 2009.

PROFESSIONAL AWARDS/HONORS

  • Junior Research Fellowship (Jan 2012 – Dec 2013) and Senior Research Fellowship (Jan 2014 – Dec 2016) from the University Grants Commission (UGC), Government of India by qualifying CSIR-UGC NET Examination to pursue PhD.
  • Nanoscale Poster Prize (Royal Society of Chemistry) in 6th International Conference on Nano Science and Technology (ICONSAT) held on Mar 03 to 05, 2014 at Panjab University, Chandigarh, India.
  • Best Poster Prize in 3rd International Conference on Advanced Nanomaterials and Nanotechnology (ICANN) held on Dec 01 to 03, 2013 at Indian Institute of Technology Guwahati (IIT Guwahati), Guwahati, India.
  • Young Scientist Presentation Award in International Conference on Nanotechnology (ICNANO) “Lessons from Nature and Emerging Technologies” held on Jul 25 and 26, 2013 at Ansal University, Gurgaon, India.

PEER – REVIEWED PUBLICATIONS (GOOGLE SCHOLAR CITATIONS: > 1680)

Articles/Communications

  • Pala, R.*; Barui, A. K.; Mohieldin, A. M.; Zhou, J.; Nauli, S. M.* Folate conjugated nanomedicines for selective inhibition of mTOR signaling in polycystic kidneys at clinically relevant doses. Biomaterials 2023, 302, 122329. ISI 2022 IF # 14.
  • Barui, A. K.; Bollu, V. S. Londhe, S.; Deshpande, S. S.; Das, S.; Nethi, S. K.; Alabbasi, M. M. A.; Kuncha, M.; Kumar, J. M.; Sistla, R.; Misra, S.; Patra, C. R.* Toxicological evaluation of therapeutically active zinc oxide nanoflowers in pre-clinical mouse model. NanoImpact 2023, 31, 100479. ISI 2022 IF # 4.9.
  • Alshammari, Q. A.; Pala, R.; Barui, A. K.; Alshammari, S. O.; Nauli, A. M.; Katzir, N.; Mohieldin, A. M.; Nauli, S. M.* The use of advanced spectral imaging to reveal nanoparticle identity in biological samples. Nanoscale 2022, 14, 4065-4072. ISI 2022 IF # 6.7. [Featured in the front cover page of the journal]
  • Nethi, S. K.;$ Barui, A. K.;$ Jhelum, P.; Basuthakur, P.; Bollu, V. S.; Reddy, B. R.; Chakravarty, S.*; Patra, C. R.* Europium hydroxide nanorods mitigate hind limb ischemia in Wistar rats. Adv. Therap. 2021, 4, 2100016. ISI 2022 IF # 4.6. [$First two authors have equal contribution]
  • Barui, A. K.;* Nethi, S. K.; Basuthakur, P.; Jhelum, P.; Bollu, V. S.; Reddy, B. R.; Chakravarty, S.*; Patra, C. R.* Therapeutic angiogenesis using zinc oxide nanoflowers for the treatment of hind limb ischemia in rat model. Biomed. Mater. 2021, 16, 044103. ISI 2022 IF # 4. [*Corresponding author]
  • Barui, A. K.; Jhelum, P.; Nethi, S. K.; Das, T.; Bhattacharya, D.; Vinothkumar, B.; Karri, S.; Chakravarty, S.*; Patra, C. R.* Potential therapeutic application of zinc oxide nanoflowers in cerebral ischemia rat model through neuritogenic and neuroprotective properties. Bioconjug. Chem. 2020, 31, 895-906. ISI 2022 IF # 4.7.
  • Jeena,  M. T.; Lee, S.; Barui, A. K.;  Jin, S.; Cho, Y.; Hwang, S-W.; Kim. S.*; Ryu, J-H.* Intra-mitochondrial self-assembly to overcome the intracellular enzymatic degradation of l-peptides. Chem. Commun. 2020, 56, 6265-6268. ISI 2022 IF # 4.9.
  • Das, S.; Roy, A.; Barui, A. K.; Alabbasi, M. M. A.; Kuncha,   M.; Sistla, R.; Sreedhar, B.;  Patra, C. R.* Anti-angiogenic vanadium pentoxide nanoparticles for the treatment of melanoma and their in vivo toxicity study. Nanoscale 2020, 12, 7604-7621. ISI 2022 IF # 6.7.
  • Bollu, V. S.;$ Bathini, T.;$ Barui, A. K.;$ Roy, A.; Ragi N. C.;  Maloth, S.; Sripadi, P.; Sreedhar, B.*; Nagababu, P.*; Patra, C. R.* Design of DNA-intercalators based copper(II) complexes, investigation of their potential anti-cancer activity and sub-chronic toxicity. Mater. Sci. Eng. C 2019, 105, 110079. ISI 2022 IF # 7.9. [$First three authors have equal contribution]
  • Nethi, S. K.; Barui, A. K.; Bollu, V. S.; B. R. Rao; Patra, C. R.* Pro-angiogenic properties of terbium hydroxide nanorods: Molecular mechanisms and therapeutic applications in wound healing. ACS Biomater. Sci. Eng. 2017, 3(12), 3635-3645. ISI 2022 IF # 5.8.
  • Barui, A. K.; Das, S.; Soanpet, P.; Sreedhar, B.; Patra, C. R.* Effective delivery of doxorubicin using biologically synthesized gold nanoparticles for cancer therapy. J. Indian Chem. Soc. 2017, 94, 1335-1348. ISI 2022 IF # 1.3.
  • Barui, A. K.; Nethi, S. K.; Patra, C. R.* Investigation of the role of nitric oxide driven angiogenesis by zinc oxide nanoflowers. J. Mater. Chem. B 2017, 5, 3391-3403. ISI 2022 IF # 7.
  • Bollu, V. S.; Barui, A. K.; Mondal, S. K.; Prashar, S.; Fajardo, M.; Briones, D.; Rodríguez-Diéguez, A.; Patra, C. R.*; Gómez-Ruiz, S.* Curcumin-loaded silica-based mesoporous materials: Synthesis, characterization and cytotoxic properties against cancer cells. Mater. Sci. Eng. C 2016, 63, 393-410. ISI 2022 IF # 7.9.
  • Kotcherlakota, R.; Barui, A. K.; Prashar, S.; Fajardo, M.; Briones, D.; Rodríguez-Diéguez, A.; Patra, C. R.*; Gómez-Ruiz, S.* Curcumin-loaded mesoporous silica: An effective drug delivery system for cancer treatment. Biomater. Sci. 2016, 4, 448-459. ISI 2022 IF # 6.6.
  • Wei, P-F.; Jin, P-P.; Barui, A. K.; Hu, Y.; Zhang, L.; Zhang, J-Q.; Shi, S-S.; Zhang, H-R.; Lin, J.; Zhou, W.; Zhang, Y-J.; Ruan, R-Q.; Patra, C. R.*; Wen, L-P.* Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment. Biomaterials 2015, 73, 160-174. ISI 2022 IF # 14.
  • Shaikh, A. C.; Shalini, S.; Vaidhyanathan, R.; Mane, M. V.; Barui, A. K.; Patra, C. R.; Venkatesh, Y.; Bangal, P. R.; Patil, N. T.* Identifying solid luminogens through gold-catalysed intramolecular hydroarylation of alkynes. Eur. J. Org. Chem. 2015, 2015(22), 4860-4867. ISI 2022 IF # 2.8.
  • Mukherjee, S.; Sreeram, P.; Barui, A. K.; Nethi, S. K.; Veeriah, V.; Chatterjee, S.; Suresh, K. I.; Patra, C. R.* Graphene oxides show angiogenic properties. Adv. Healthc. Mater. 2015, 4(11), 1722-1732. ISI 2022 IF # 10. [Highlighted in “Nature India” and “Chemistry Views”]
  • Patra, S.; Mukherjee, S.; Barui, A. K.; Ganguly, A.; Sreedhar, B.; Patra. C. R.* Green synthesis, characterization of gold and silver nanoparticles and their potential application for cancer therapeutics. Mater. Sci. Eng. C 2015, 53, 298-309. ISI 2022 IF # 7.9.
  • Kulhari, H.; Pooja, D.; Shrivastava, S.; Telukutala, S. R.; Barui, A. K.; Patra, C. R.; Vegi, G. M. N.; Adams, D. J.; Sistla, R.* Cyclic-RGDfK peptide conjugated succinoyl-TPGS nanomicelles for targeted delivery of docetaxel to integrin receptor over-expressing angiogenic tumours. Nanomedicine: Nanotechnology, Biology, and Medicine 2015, 11, 1511-1520. ISI 2022 IF # 5.4.
  • Nethi, S. K.; Veeriah, V.; Barui, A. K.; Rajendran, S.; Mattapally, S.; Misra, S.; Chatterjee, S.*; Patra, C. R.* Investigation of molecular mechanisms and regulatory pathways of pro-angiogenic nanorods. Nanoscale 2015, 7, 9760-9770. ISI 2022 IF # 6.7.
  • Pal, A.; Ganguly, A.; Chowdhuri, S.; Yousuf, M.; Ghosh, A.; Barui, A. K.; Kotcherlakota, R.; Adhikari, S.*; Banerjee, R.* Bis-arylidene oxindole-betulinic acid conjugate: A fluorescent cancer cell detector with potent anticancer activity. ACS Med. Chem. Lett. 2015, 6, 612-616. ISI 2022 IF # 4.2.
  • Adela, R.; Nethi, S. K.; Bagul, P. K.; Barui, A. K.; Mattapally, S.; Kuncha, M; Patra, C. R.; Reddy, P. N. C.; Banerjee, S. K.* Hyperglycaemia enhances nitric oxide production in diabetes: A study from south Indian patients. Plos One 2015, 10(4), e0125270. ISI 2022 IF # 3.7.
  • Nagababu, P.;$* Barui, A. K.;$ Thulasiram, B.;$ Devi, C. S.; Satyanarayana, S.; Patra, C. R.*; Sreedhar, B.* Antiangiogenic activity of mononuclear copper(II) polypyridyl complexes for the treatment of cancers. J. Med. Chem. 2015, 58, 5226-5241. ISI 2022 IF # 7.3. [$First three authors have equal contribution]
  • Nethi, S. K.; Mukherjee, S.; Veeriah, V.; Barui, A. K.; Chatterjee, S.; Patra, C. R.* Bioconjugated gold nanoparticles accelerate the growth of new blood vessels through redox signalling. Chem. Commun. 2014, 50, 14367-14370. ISI 2022 IF # 4.9. [Highlighted in “Nature India” and “Hindustan Times”]
  • Wei, P-F.; Zhang, L.; Nethi. S. K.; Barui, A. K.; Lin, J.; Zhou, W.; Shen, Y.; Mana, N.; Zhang, Y-J.; Xu, J.; Patra, C. R.*; Wen, L-P.* Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods. Biomaterials 2014, 35(3), 899-907. ISI 2022 IF # 14.
  • Chereddy, N. R.*; Krishnan, S.; Barui, A. K.; Patra, C. R.*; Vaidya J. R.*; Thennarasu, S.* Donor atom selective coordination of Fe3+ and Cr3+ trigger fluorophore specific emission in a rhodamine–naphthalimide dyad. RSC Adv. 2014, 4, 24324-24327. ISI 2022 IF # 3.9.
  • Gayathri, T.;$ Barui, A. K.;$ Prashanthi, S.; Patra, C. R.*; Singh, S. P.* Meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity. RSC Adv. 2014, 4, 47409-47413. ISI 2022 IF # 3.9. [$First two authors have equal contribution]
  • Modak, A.;$ Barui, A. K.;$ Patra, C. R.*; Bhaumik, A.* A luminescent nanoporous hybrid material – based drug delivery system showing excellent theranostics potential for cancer. Chem. Commun. 2013, 49, 7644-7646. ISI 2022 IF # 4.9. [Highlighted in “Nature India”] [$First two authors have equal contribution]
  • Mukherjee, S.; Sushma, V.; Patra, S.; Barui, A. K.; Bhadra, M. P.; Sreedhar, B.; Patra, C. R.* Green chemistry approach for the synthesis and stabilization of biocompatible gold nanoparticles and their potential applications in cancer therapy. Nanotechnology 2012, 23, 455103. ISI 2022 IF # 3.5. [Highlighted in “Nature India”, “The Hindu” and “Global Medical Discovery Alert”]
  • Patil, N. T.*; Shinde, V. S.; Thakare, M. S.; Kumar, P. H.; Bangal, P. R.; Barui, A. K.; Patra, C. R.* Exploiting the higher alkynophilicity of Au-species: Development of a highly selective fluorescent probe for gold ions. Chem. Commun. 2012, 48, 11229-11231. ISI 2022 IF # 4.9.
  • Barui, A. K.; Veeriah, V.; Mukherjee, S.; Manna, J.; Patel, A. K.; Patra, S.; Pal, K.; Murali, S.; Rana, R. K.; Chatterjee, S.; Patra, C. R.* Zinc oxide nanoflowers make new blood vessels. Nanoscale 2012, 4(24), 7861-7869. ISI 2022 IF # 6.7. [Highlighted in “Nature India”, “The Hindu” and “Smart Brief”]

Review Articles

  • Barui, A. K.; Oh, J. Y.; Jana, B.; Kim, C.*; Ryu, J-H.* “Cancer-targeted nanomedicine: overcoming the barrier of protein corona”. Adv. Therap. 2020, 3, 1900124. ISI 2022 IF # 4.6.
  • Barui, A. K.; Nethi, S. K.; Haque, S.; Basu Thakur, P.; Patra, C. R.* “Recent development of metal nanoparticles for angiogenesis study and their therapeutic applications”. ACS Appl. Bio Mater. 2019, 2, 5492-5511. ISI 2022 IF # 4.7.
  • Nethi, S. K.;$ Barui, A. K.;$ Mukherjee, S.;$ Patra, C. R.* “Engineered nanoparticles for effective redox signaling during angiogenic and anti-angiogenic therapy”. Antioxid. Redox Signal. 2019, 30, 786-809. ISI 2022 IF # 6.6. [$First three authors have equal contribution]

Editorial

  • Patra, C. R.*; Barui, A. K. Nanoflowers: A future therapy for cardiac and ischemic disease? Nanomedicine 2013, 8(11), 1735-1738. ISI 2022 IF # 5.5.

Book Chapters

  • Mishra, A.*; Singla, S.; Barui, A. K.* “Green synthesis of inorganic nanoparticles and their cancer theranostics applications”; Book title: “Biogenic Nanoparticles for Cancer Theranostics”; Editor: Dr. Chittaranjan Patra et al.; Elsevier, 2021; ISBN: 978-012-82-1467-1. [*Corresponding author]
  • Barui, A. K.; Roy, A.; Das, S.; Bhamidipati, K.; Patra, C. R.* “Therapeutic applications of graphene oxides in angiogenesis and cancers”; Book title: “Nanoparticles and Their Biomedical Applications”; Editor: Dr. Ashutosh K. Shukla; Springer Nature, 2020; ISBN: 978-981-15-0391-7.
  • Barui, A. K.;$ Jana, B.;$ Ryu, J. H.* “An insight into characterizations and applications of nanoparticulate targeted drug delivery systems”; Book title: “Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy”; Editor: Dr. SSR Kumar Challa; Springer Nature, 2019; ISBN: 978-3-662-59596-1. [$First two authors have equal contribution]
  • Barui, A. K.; Das, S.; Patra, C. R.* “Biomedical applications of green synthesized metal nanoparticles using Polysaccharides”; Book title: “Functional Polysaccharides for Biomedical Applications”; Editor: Prof. Sougata Jana and Prof. Sabyasachi Maiti; Elsevier Inc., 2019; DOI: 10.1016/B978-0-08-102555-0.00010-8.; ISBN: 978-0-08-102555-0.
  • Barui, A. K.; Kotcherlakota, R.; Patra, C. R.* “Biomedical applications of zinc oxide nanoparticles”; Book title: “Inorganic Frameworks as Smart Nanomedicines”; Editor: Dr. Alexandru Mihai Grumezescu; Publisher: Elsevier-William Andrew, Copyright holder: Elsevier Inc., Oxford, UK and Cambridge, USA; 2018; DOI: 10.1016/B978-0-12-813661-4.00006-7; ISBN: 978-0-12-813661-4.
  • Barui, A. K.; Kotcherlakota, R.; Patra, C. R.* “Medicinal applications of metal nanoparticles”; Book title: “Metal Nanoparticles: Synthesis and Applications in Pharmaceutical Sciences”; Editor: Prof. Sreekanth Thota and Prof. Debbie C. Crans; Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany; 2018; DOI: 10.1002/9783527807093.ch6; ISBN: 978-3-527-33979-2.
  • Barui, A. K.; Kotcherlakota, R.; Bollu, V. S.; Nethi, S. K.; Patra, C. R.* “Biomedical and drug delivery applications of functionalized inorganic nanomaterials”; Book title: “Biopolymer-Based Composites: Drug Delivery and Biomedical Applications”; Editor: Prof. Sougata Jana, Prof. Sabyasachi Maiti and Prof. Subrata Jana; Publisher: Woodhead Publishing; Copyright holder: Elsevier Ltd., Duxford, UK, Cambridge, USA and Kidlington, UK; 2017; DOI: 10.1016/B978-0-08-101914-6.00011-9; ISBN: 978-0-08-101914-6 (print); ISBN: 978-0-08-101915-3 (online).
  • Kulhari, H.; Pooja, D.; Shrivastava, S.; Reddy, T. S.; Barui, A. K.; Patra, C. R.; Naidu, V. G. M.; Adams, D. J.; Sistla, R.* “Cyclic-RGDfK-directed docetaxel loaded nanomicelles for angiogenic tumor targeting” in “Springer Protocols”; Series title: “Methods in Pharmacology and Toxicology”; Publisher: Humana Press; Copyright holder: Springer Science + Business Media, New York; 2015; DOI: 10.1007/7653_2015_63; ISBN: 978-1-4939-7443-6 (print); ISBN: 978-1-4939-7445-0 (online).

PROFESSIONAL ACTIVITIES

Role as Editor

  • Editorial Board Member – Springer Nature (BMC Cancer, UK; ISI 2022 IF#3.8)
  • Topic Editor – MDPI, Switzerland [Cancers (ISI 2022 IF#5.2), Pharmaceutics (ISI 2022 IF#5.4), Nanomaterials (ISI 2022 IF#5.3), Biomedicines (ISI 2022 IF#4.7) & J. Clin. Med. (ISI 2022 IF#3.9)]

Role as Invited Reviewer

  • Acta Biomaterialia (Elsevier, Netherlands; ISI 2022 IF # 9.7)
  • Materials Science and Engineering C (Elsevier, Netherlands; ISI 2022 IF # 7.9)
  • Journal of Materials Chemistry B (Royal Society of Chemistry, UK; ISI 2022 IF # 7)
  • Nanoscale (Royal Society of Chemistry, UK; ISI 2022 IF # 6.7)
  • Biomaterials Science (Royal Society of Chemistry, UK; ISI 2022 IF # 6.6)
  • Food & Function (Royal Society of Chemistry, UK; ISI 2022 IF # 6.1)
  • Colloids and Surfaces B: Biointerfaces (Elsevier, Netherlands; ISI 2022 IF # 5.8)
  • European Journal of Medical Research (Springer Nature, Germany; ISI 2022 # 4.2)
  • RSC Advances (Royal Society of Chemistry, UK; ISI 2022 IF # 3.9)
  • Royal Society Open Science (The Royal Society Publishing, UK; ISI 2022 IF # 3.5)
  • New Journal of Chemistry (Royal Society of Chemistry, UK; ISI 2022 IF # 3.3)

Association with Scientific Body

  • Member (MRSC) of the prestigious Royal Society of Chemistry (RSC), UK | Jul 2019 – Present
  • Member of the prestigious American Heart Association (AHA), USA | Nov 2022 – Present

Scientific Blogger

  • Scientific Blog in RSC Advances (Royal Society of Chemistry, UK; ISI 2022 IF # 3.9) highlighting therapeutic application of a photothermally triggered nanoplatform based on IR780-encapsulated PLGA nanoparticles for breast cancer metastasis to bones | Link: RSC Advances Blog

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