Ashraf M. Mohieldin


Contact:      

Ashraf M. Mohieldin, Ph.D.
Research Associate
Chapman University School of Pharmacy
Harry and Diane Rinker Health Science Campus
9401 Jeronimo Road, Irvine, CA 92618
Office: (714) 516-5447 | Fax: (714) 516-5481

 

EDUCATION:

  • Ph.D. Degree in Medicinal Chemistry, August 2015, School of Pharmacy, The University of Toledo, OH, USA.
  • B.S. Degree in Doctor of Pharmacy, May 2016, College of Pharmacy, University of Toledo, 3000 Arlington Ave, Toledo, OH, USA.
  • B.S. Degree in Pharmaceutical Science with Departmental Honors, May 2011, College of Pharmacy, University of Toledo, 3000 Arlington Ave, Toledo, OH, USA.

RESEARCH INTERESTS:

  • Examine the ciliary extracellular-like vesicle structure, function, physiological relevance, and ciliopathy disorder signaling pathway.
  • Advancing biotechnology techniques to target cilia using inovative drug delivery system to treat ciliopathy hypertension.
  • Advancing biotechnology techniques to study single-cell-single-cilium and optimizing proteomic approach to study novel ciliary proteins.

PHARMACY PRACTICE EXPERIENCE:

  • Community pharmacy, Rite Aid Pharmacy, Toledo, OH, January 2015 to December 2015.
  • Participated in a diabetes self-management education class, University of Toledo, Medical center, Toledo, OH,  March 2015.

RESEARCH EXPERIENCE AND APPOINTMENTS:

  • Reviewer Board member of Medicina scientific journal, Basel, Switzerland. November 2020 to present.
  • Research Associate in Pharmaceutical and Biomedical Sciences, School of Pharmacy, Chapman University, CA, USA. February 2020 to present.
  • Post-Doctoral Fellow in Pharmaceutical and Biomedical Sciences, School of Pharmacy, Chapman University, CA, USA. February 2016 to February 2020.
  • Research Assistant, University of Toledo, Medical center, Toledo, OH, May 2011 to August 2011.
  • Departmental Honor Thesis (Pharmacology), University of Toledo, Medical center, Toledo, OH – Surya M. Nauli, PhD, January 2010 to May 2011.
  • Research Assistant, University of Toledo, Medical center, Toledo, OH, PhD, January 2009 to May 2009.
  • Research Assistant, University Of Massachusetts Boston, Boston, MA, May 2008 to August 2008.
  • Research Assistant, University of Toledo, Toledo, OH, Chemical Supervisor, August 2007 to May 2008.
  • Research Assistant, Bunker Hill College, Cambridge, MA, May 2005 to May 2007.

PROFESSIONAL AWARDS AND NEWS MEDIA:

  • News release in Wiley publisher YouTube web-page, highlighting the new revelation of ciliary extracellular vesicles’ role in cardiovascular functions. January 2021: https://youtu.be/iD6O4llHW9k
  • News release in the American Association for the Advancement of Science to highlight the most recent publication, Research reveals cilia’s role in cardiovascular functions and genetic diseases, August, 2020: https://www.eurekalert.org/pub_releases/2020-08/cu-rrc081920.php
  • Acknowledgment of peer-reviewing scientific articles in the International Journal of Environmental Research and Public Health in the year 2020. IJERPH Editorial Office. Acknowledgment to Reviewers of IJERPH in 2020. Int. J. Environ. Res. Public Health 2021, 18, 1259. https:// doi.org/10.3390/ijerph18031259.
  • NIH F31 fellowship award, University of Toledo, Medical center, Toledo, OH, 2012-2015
  • Departmental Honor Thesis, University of Toledo, Medical center, Toledo, OH, May 2011
  • Dean’s list, University of Toledo, Medical center, Toledo, OH, spring 2011
  • Dean’s list, University of Toledo, Medical center, Toledo, OH, spring 2009
  • Dean’s list, University of Toledo, Medical center, Toledo, OH, Fall 2008
  • Dean’s list, University of Toledo, Medical center, Toledo, OH, spring 2009

PEER-REVIIEWED SCIENTIFIC ARTICLES:

  • Peer-reviewed numerous of scientific articles, short communication, review articles and case reports for different scientific journals.

BOOK CHAPTER PUBLICATIONS:

  • Mohieldin AM, Alanazi M, Nauli A, Nauli S. Mechanobiology of primary cilia in the vascular and renal systems; Mechanobiology in Health and Disease, ELSEVIER, (2018). Chapter 10. https://doi.org/10.1016/B978-0-12-812952-4.00010-6

 

  • Mohieldin AM, Zubayer HS, Al Omran AJ, Saternos HC, Zarban AA, Nauli SM, AbouAlaiwi WA. Vascular Endothelial Primary Cilia: Mechanosensation and Hypertension. Current hypertension reviews. 2016; 12(1):57-67. PubMed [journal] PMID: 261223292.

 

  • Kathem SH, Mohieldin AM, Nauli SM. The Roles of Primary cilia in Polycystic Kidney Disease. AIMS molecular science. 2014; 1(1):27-46. NIHMSID: NIHMS647178PubMed [journal] PMID: 25599087, PMCID: PMC4296740.

 

  • Mohieldin AM, Upadhyay V, M Ong l, Nauli S. Autosomal Dominant Polycystic Kidney Disease: Pathophysiology and Treatment; Autosomal Dominant Disorders: New Research, Nova Science Publishers, (2013). Chapter 1, p.pp. 1 32. 120p.

SLECTED PEER-REVIIEWED PUBLICATIONS:

  • Mohieldin AM, Pala R, Richard Beuttler, Moresco JJ, Yates III JR, Nauli SM. Ciliary extracellular vesicles are distinct from the cytosolic extracellular vesicles, J Extracell Vesicles. 2021 Apr;10:e12086. doi:10.1002/jev2.12086. Epub 2021 Apr 27. (Impact factor 14.97).

 

  • Mohieldin AM, Pala R, Sherpa RT, Alanazi M, Alanazi A, Shamloo K, Ahsan A, AbouAlaiwi WA, Moresco JJ, Yates III JR, Nauli SM. Proteomic Identification Reveals the Role of Ciliary Extracellular‐Like Vesicle in Cardiovascular Function.  Adv Sci (Weinh). 2020; 7:1903140. [FEATURED IN THE FRONT-PAGE JOURNAL]. (Impact factor 15.84).

 

  • Rajasekharreddy Pala, Ashraf M. Mohieldin, Rinzhin T. Sherpa, Sarmed H. Kathem, Kiumars Shamloo, Zhongyue Luan, Jing Zhou, Jian-Guo Zheng, Amir Ahsan, and Surya M. Nauli. Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles. ACS Nano 2019 13 (3), 3555-3572. 2. (Impact factor 14.58).

 

  • Sherpa RT, Pala R, Mohieldin AM, Nauli SM. Measurement of cytoplasmic and cilioplasmic calcium in a single living cell. Methods Cell Biol. 2019;153:25-42. doi: 10.1016/bs.mcb.2019.03.015. Epub 2019 Apr 17. PMID: 31395382; PMCID: PMC7899241. (Impact factor 1.44).

 

  • Sherpa RT, Mohieldin AM, Pala R, Wachten D, Ostrom RS, Nauli SM. Sensory primary cilium is a responsive cAMP microdomain in renal epithelia. Sci Rep. 2019 Apr 25;9(1):6523. doi: 10.1038/s41598-019-43002-2. Erratum in: Sci Rep. 2020 Jan 29;10(1):1731. PMID: 31024067; PMCID: PMC6484033. (Impact factor 3.99).

 

  • Pala R, Mohieldin AM, Shamloo K, Sherpa RT, Kathem SH, Zhou J, Luan Z, Zheng JG, Ahsan A, Nauli SM. Personalized Nanotherapy by Specifically Targeting Cell Organelles To Improve Vascular Hypertension. Nano Lett. 2019 Feb 13;19(2):904-914. doi: 10.1021/acs.nanolett.8b04138. Epub 2018 Dec 26. PMID: 30582331; PMCID: PMC7899193. (Impact factor 11.23).

 

  • Doerr N, Wang Y, Kipp KR, Liu G, Benza JJ, Pletnev V, Pavlov TS, StaruschenkoA, Mohieldin AM, Takahashi M, Nauli SM, Weimbs T. Regulation of Polycystin-1Function by Calmodulin Binding. PLoS One. 2016 Aug 25;11(8): e0161525. doi:10.1371/journal.pone.0161525. eCollection 2016. PubMed PMID: 27560828; PubMedCentral PMCID: PMC4999191.2: (Impact factor 2.80).

 

  • Mohieldin AM, AbouAlaiwi WA, Gao M, Nauli SM. Chemical-Free Technique to Study the Ultrastructure of Primary Cilium. Scientific reports. 2015; 5:15982. PubMed [journal] PMID: 26521680, PMCID: PMC4629161. (Impact factor 5.75).

 

  • Mohieldin AM, Zubayer HS, Al Omran AJ, Saternos HC, Zarban AA, Nauli SM, AbouAlaiwi WA. Vascular Endothelial Primary Cilia: Mechanosensation and Hypertension. Curr Hypertens Rev. 2016;12(1):57-67. doi: 10.2174/1573402111666150630140615. PMID: 26122329. (Impact factor 1.35).

 

  • Mohieldin AM, Haymour HS, Lo ST, AbouAlaiwi WA, Atkinson KF, Ward CJ, Gao M, Wessely O, Nauli SM. Protein composition and movements of membrane swellings associated with primary cilia. Cell Mol Life Sci. 2015 Jun;72(12):2415-29. doi: 10.1007/s00018-015-1838-x. Epub 2015 Feb 4. PMID: 25650235; PMCID: PMC4503369. (Impact factor 6.39).

 

  • Kathem SH, Mohieldin AM, Abdul-Majeed S, Ismail SH, Altaei QH, Alshimmari IK, Alsaidi MM, Khammas H, Nauli AM, Joe B, Nauli SM. Ciliotherapy: a novel intervention in polycystic kidney disease. J Geriatr Cardiol. 2014 Mar;11(1):63-73. doi: 10.3969/j.issn.1671-5411.2014.01.001. PMID: 24748884; PMCID: PMC3981986. (Impact factor 2.49).

 

  • Kathem SH, Mohieldin AM, Nauli SM. The Roles of Primary cilia in Polycystic Kidney Disease. AIMS Mol Sci. 2014;1(1):27-46. doi: 10.3934/molsci.2013.1.27. PMID: 25599087; PMCID: PMC4296740.

 

  • Jin X, Mohieldin AM, Muntean BS, Green JA, Shah JV, Mykytyn K, Nauli SM. Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli. Cell Mol Life Sci. 2014 Jun;71(11):2165-78. doi: 10.1007/s00018-013-1483-1. Epub 2013 Oct 9. PMID: 24104765; PMCID: PMC3981964. (Impact factor 6.39).