Sarmed Kathem

 

Contact:       
Office:  Chapman University, School of Pharmacy, Health Science Campus
.             9401 Jeronimo road, Irvine, CA 92618
Phone:  714-516-5449
Email:  kathem@chapman.edu;  ksarmed@uci.edu

Education:  
B.Sc. Pharmacy (1998), University of Baghdad
M.Sc. Pharmacology and Toxicology (2005), University of Baghdad
Ph.D. Pharmacology and Toxicology (2013), University of Baghdad

Biography:      
I earned a B.Sc. degree in Pharmacy from University of Baghdad in 1998. I worked in Ibn-Alnafees Hospital as a clinical pharmacist, then I changed my carrier to the academic field. I worked in the college of Pharmacy, University of Baghdad as a teaching assistant (1999) then I received my M.Sc. in pharmacology (2004) followed by Ph.D. in pharmacology (2012) from the University of Baghdad. I appointed as a tenure faculty in the College of Pharmacy, University of Baghdad from 2005 till now.

I enrolled in the primary cilia research group with Dr. Surya Nauli in the University of Toledo in 2012, then I also re-joined with Dr. Nauli to pursue our research in Chapman University in 2014.

I am a faculty in the College of Pharmacy University of Baghdad, visiting research faculty in Chapman University, member in professional societies (ASPET, Iraqi Pharmacists Syndicate), reviewer in scientific journals, and participating in many conferences and workshops.

Research Interest:
My previous research focused on the molecular components of primary cilia mechanosensory and chemosensory functions in endothelial cells. The research focused on the role primary cilia in coordinating the dopaminergic and NO signaling of endothelial cells in polycystic kidney disease. That research includes in vitro models and clinical studies. In addition, the role of primary cilia in planer cell polarity also explored in relation to PKD. The current research looking for more signaling pathways regulated by primary cilia in endothelial and renal epithelial cells, these signaling pathways expected to have pharmacological impact on polycystic kidney disease.

Our experimental and clinical research intending: 1) to increase our knowledge on the role of primary cilia in disease, specially the cardiovascular component of polycystic kidney disease like hypertension; 2) to find cilia-related molecular targets to be utilized for therapeutic purposes.

We are pursuing our research on primary cilia aiming to translate our experimental findings into clinical practice in an attempt to shed the light on the way to pharmacologically rescue primary cilia function or what is called ciliotherapy.

Publications:

  • Waleed K. Abdulsahib, Adeeb Al-Zubaidy, Hayder B. Sahib, Sarmed H. Kathem. Tolaerable ocular hypotensive effect of topically applied sildenafil in ocular normotensive and betamethasone-induced hypertensive rabbits. J. Pharm. Sci. Rev. Res. 2015; 35(1), 96:102.
  • Kimberly F. Atkinson, Sarmed H. Kathem, Xingjian Jin, Brian S. Muntean, Wissam A. Abou-Alaiwi, Andromeda M. Nauli and Surya M. Nauli . Dopaminergic signaling within the primary cilia in the renovascular system. Front Physiol. 2015 16;6:103.
  • Surya M. Nauli, Kimberly F. Atkinson, Sarmed H. Kathem. The cell’s antenna. International Innovation 2015; 170:94-96
  • Sarmed H. Kathem, Ashraf M. Mohieldin, Shakila Abdul-Majeed, Sajida H. Ismail, Qaiss H. Altaei, Ibrahim K. Alshimmari, Mohanned M. Alsaidi, Hussein Khammas, Andromeda M. Nauli, Bina Joe, Albert C. Ong, Surya M. Nauli. Ciliotherapy: a novel intervention in polycystic kidney disease. J Geriatr Cardiol 2014; 11: 1
  • Viralkumar S. Upadhyay, Brian S. Muntean, Sarmed H. Kathem, Jangyoun J. Hwang, Wissam A. AbouAlaiwi and Surya M. Nauli. Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells. Physiol. 2014, 5:72.
  • Sarmed H. Kathem , Ashraf M. Mohieldin , Surya M. Nauli. The Roles of Primary cilia in Polycystic Kidney Disease. AIMS Molecular Science 2013, 1: 27-46.
  • Sarmed H. Kathem, Ismail S. H. Effect of Fenoldopam on Cytosolic Nitric Oxide Production in Pkd1 Isolated Femoral Arteries in Response to Fluid Shear Stress Ex Vivo. J Phys Pharm Adv 2013, 3(4): 121-126.
  • Sarmed H. Kathem, Dawser Ismail, Sajida Ismail, Khalid Hussain. Effects of non-steroidal antiinflammatory drugs on the glycemic state and inflammatory marker in poorly controlled type II DM patients. Al-Mustansiriyah Journal for Pharmaceutical Sciences. 2006;3:46-51.
  • Sarmed H. Kathem, Ashraf M. Mohieldin, Shakila Abdul-Majeed, Sajida H. Ismail, Qaiss H. Altaei, Ibrahim K. Alshimmari, Mohanned M. Alsaidi, Hussein Khammas, Andromeda M. Nauli, Bina Joe, Albert C. Ong, Surya M. Nauli. Ciliotherapy: a novel intervention in polycystic kidney disease. J Geriatr Cardiol 2014; 11: 1-11. doi:10.3969
  • Viralkumar S. Upadhyay, Brian S. Muntean, Sarmed H. Kathem, Jangyoun J. Hwang, Wissam A. AbouAlaiwi and Surya M. Nauli. Roles of dopamine receptor on chemosensory and mechanosensory primary cilia in renal epithelial cells. Front. Physiol. 2014, 5:72. doi:10.3389
  • Sarmed H. Kathem , Ashraf M. Mohieldin , Surya M. Nauli. The Roles of Primary cilia in Polycystic Kidney Disease. AIMS Molecular Science 2013, 1: 27-46. doi:10.3934
  • Sarmed H. Kathem, Dawser Ismail, Sajida Ismail, Khalid Hussain. Effects of non-steroidal antiinflammatory drugs on the glycemic state and inflammatory marker in poorly controlled type II DM patients. Al-Mustansiriyah Journal for Pharmaceutical Sciences. 2006;3:46-51.