Selected Recent Publication

Area of Neurotherapeutics:

J. Marshall, J. Szmydynger-Chodobska, M.S Rioult-Pedotti, K. Lau, A. T. Chin, S. K. R. Kotla, R. K. Tiwari, K. Parang, S. W. Threlkeld, and A. Chodobski. TrkB-enhancer facilitates functional recovery after traumatic brain injury. Scientific Reports, 2017, Sep 8;7(1):10995. doi: 10.1038/s41598-017-11316-8. PMID: 28887487.

S. Darwish, K. Parang, J. Marshall, D. J. Goebel, R. Tiwari*. Efficient synthesis of CN2097 using in situ activation of sulfhydryl group. Tetrahedron Letters, 2017, 58, 3053-3056. DOI: 10.1016/j.tetlet.2017.06.066.

J. Marshall, K. Y. Wong, K. Parang, R. Tiwari, M. R. Spaller, C. N. Rupasinghe, E. D. Berberoglu, X. Zhao, C. Sinkler, J. Liu, I. Lee, M. Huttemann, and D. J. Goebel. Inhibition of NMDA-induced retinal neuronal death by polyarginine peptides is linked to the attenuation of stress-induced hyperpolarization of the inner mitochondrial membrane potential. Journal of Biological Chemistry, 2015, 290(36), 22030-22048.

M. Sharma*, M. Tiwari, R. K. Tiwari*. Hyperhomocysteinemia: Impact on Neurodegenerative Diseases. Basic & Clinical Pharmacology Toxicology. 2015, 117(5), 287-296. doi: 10.1111/bcpt.12424. PMID:26036286. 

C. Cao, M. S. Rioult-Pedotti, P. Migani, C. J. Yu, R. Tiwari, K. Parang, M. R. Spaller, D.J. Goebel, and J. Marshall. Impairment of TrkB-PSD-95 signaling in Angelman syndrome. PLoS Biology, 2013, 11(2):e1001478.


Area of Cancer:

R. K. Tiwari,* A. Brown, A. N. Shirazi, J. Bolton, A. Tse, G. Verkhivker,* K. Parang,* and G. Sun*. Design, synthesis, and evaluation of dasatinib-amino acid and dasatinib-fatty acid conjugates as Protein Tyrosine Kinase Inhibitors. ChemMedChem, 2017, 12(1), 86-99. doi: 10.1002/cmdc.201600387. PMID: 27875633.

A. Banerjee, N. Sayeh, A. N. Shirazi, R. Tiwari, K. Parang, A. Yadav. Arginine-rich cyclic peptides enhance nuclear targeted delivery of anti-cancer agents: Molecular insights. Letters in Drug Design & Discovery, 2016, 13, 591-604.

S. Mokhtari. A. N. Shirazi, R. K. Tiwari, K. Parang, and Farzad Kobarfard. Synthesis of 3-Arylidene and 3-Arylimine Oxindole Derivatives and Evaluation of Their Src Kinase Inhibitory and Antiproliferative Activities. Medicinal Chemistry, 2015, 5(6), 242-252. Doi: 10.4172/2161-0444.1000271. 

K. Chand, R. K. Tiwari, S. Kumar, A. N. Shirazi, S. Sharma, E. V. V. D. Eycken, V. S. Parmar, K. Parang, and S. K. Sharma. Synthesis, antiproliferative, and c-Src kinase inhibitory, activities of 4-Oxo-4H-1-benzopyran derivatives. J. Heterocyclic Chemistry, 2015, 52, 562-572.

K. Chand, S. Prasad, R. K. Tiwari, A. N. Shirazi, S. Kumar, K. Parang, and S. Sharma. Synthesis and Evaluation of c-Src Kinase Inhibitory Activity of Pyridin-2(1H)-one Derivatives. Bioorganic Chemistry, 2014, 53, 75-82.

S. Motavallizadeh, A. Fallah-Tafti, S. Maleki, A. N. Shirazi, M. Pordeli, M. Safavi, S. K. Ardestani, S. Asd, R. Tiwari, D. Oh, A. Shafiee, A. Foroumadi, K. Parang, and T. Akbarzadeh. Synthesis and evaluation of cytotoxic activity of substituted N-(9-oxo-9H-xanthen-4-yl)benzenesulfonamides. Tetrahedron Letters, 2014, 55, 373-375.

B. P. Pemmaraju, S. Mallekar, H. K. Agarwal, R. K. Tiwari, D. Oh, G. F. Doncel, D. R. Worthen, K. Parang. Design, Synthesis, Antiviral Activity, and Pre-formulation Development of Poly-L-Arginine-Fatty acyl Derivatives of Nucleoside Reverse Transcriptase Inhibitors. Nucleosides, Nucleotides and Nucleic Acids. 2015, 34 (1), 1-15.


Area of Antimicrobial Drug:

N. Riahifard, K. Tavakoli, J. Yamaki, K. Parang*, R. Tiwari*. Synthesis and Evaluation of Antimicrobial Activity of [R4W4K]-Levofloxacin and [R4W4K]-Levofloxacin-Q Conjugates. Molecules, 2017, 22(6). PMID: 28594345. DOI: 10.3390/molecules22060957. 


Area of Peptide based Drug Delivery:

M. Sharma, N.S. El-Sayed, H. Do, K. Parang, R. K. Tiwari* and H. Aliabadi*. Tumor-targeted delivery of siRNA using fatty acyl-CGKRK peptide conjugates. Scientific Reports , 2017,  Jul 21;7(1):6093. doi: 10.1038/s41598-017-06381-y. PMID: 28733622.

N.S. El-Sayed, A. N. Shirazi, M.G. El-Meligy, A.K. EL-Ziaty, Z.A. Nagieb*, K. Parang*, R. K. Tiwari*. Design, synthesis, and evaluation of chitosan conjugated GGRGDSK peptides as a cancer cell-targeting molecular transporter. International Journal of Biological Marcromolecules, 2016, 87, 611-622. PMID: 26976071. 

D. Weerakkody, A. Moshnikova, N. S. El-Sayed, R. C. Adochite, G. Slaybaugh, J. Golijanin, R. K. Tiwari, O.A. Andreev, K. Parang, Y. K. Reshetnyak. Novel pH-Sensitive Cyclic Peptides. Scientific Report 2016, 12(6), 31322. doi: 10.1038/srep31322. PMID: 27515582. 

A. N. Shirazi, N. S. El-Sayed, D. Mandal, R. K. Tiwari, K. Tavakoli, M. Estesham, K. Parang. Cysteine and arginine-rich peptides as molecular carriers. Bioorg Med Chem Lett. 2016, 26(2), 656-661. doi: 10.1016/j.bmcl.2015.11.052. PMID: 26631317. 

A. N. Shirazi, N.S. El-Sayed, K. Tavakoli, R. K. Tiwari, K. Parang. Cyclic Peptide Containing Hydrophobic and Positively Charged Residues as a Drug Delivery System for Curcumin. Curr Drug Deliv. 2016,13(3), 409-417. PMID: 26511089.

D. Oh, S. A. Darwish, A. N. Shirazi, R. K. Tiwari, and K. Parang. Amphiphilic Bicyclic Peptides as Cellular Delivery Agents. Chemmedchem, 2014, 9(11), 2449-2453.

N. Sayeh, A. N. Shirazi, D. Oh, J. Sun, D. Rowley, A. Banerjee, A. Yadav, R. K. Tiwari*, and K. Parang*. Amphiphilic Triazolyl Peptides: Synthesis and Evaluation as Nanostructures. Current Organic Chemistry, 2014, 18(20), 2665-2671.

A. N. Shirazi, R. Tiwari, D. Oh, B. Sullivan, A. Kumar, Y. Beni, and K. Parang. Cyclic Peptide-Selenium Nanoparticles as Drug Delivery Systems. Molecular Pharmaceutics, 2014, 11(10), 3631-3641.

A. N. Shirazi, D. OH, R. K. Tiwari, B. Sullivan, A. Gupta, G. Bothun, and K. Parang. Peptide-Amphiphile Containing Arginine and Fatty Acyl Chains as Molecular Transporters. Molecular Pharmaceutics, 2013, 10 (12), 4717–4727.

D. Oh, A. N. Shirazi, K. Northup, B. Sullivan, R. K. Tiwari, M. Bisoffi, and K. Parang. Enhanced Cellular Uptake of Short Polyarginine Peptides through Fatty Acylation and Cyclization. Molecular Pharmaceutics, 2014, 11 (8), 2845–2854.

B. Pemmaraju, H. K. Agarwal, D. Oh, K. W. Buckheit, R. W. Buckheit Jr., R. Tiwari, K. Parang. Synthesis and Biological Evaluation of 5′-O-Dicarboxylic Fatty Acyl Monoester Derivatives of Anti-HIV Nucleoside Reverse Transcriptase Inhibitors. Tetrahedron Letters, 2014, 55(12), 1983-1986.

K. Pericherla, A. N. Shirazi, V. K. Rao, R. K. Tiwari, N. Dasilva, K.T. Mccaffrey, Y. A. Beni, A. González-Sarrías, N. P. Seeram, K. Parang, and A. Kumar. Synthesis and antiproliferative activities of quebecol and its analogs. Bioorganic & Medicinal Chemistry Letters, 2013, 23(19), 5329-5331.

D. Mandal, R. K. Tiwari, A. N. Shirazi, G. Ye, A. Banerjee, A. Yadav, and K. Parang. Self-Assembled Surfactant Cyclic Peptides As Stabilizing Agents. Soft Matter, 2013, 9, 9465-9475.


Area of  Synthetic Chemistry:

S. K. R. Kotla, J. K. Vandavasi, Jeh-Jeng Wang, K. Parang and R. K. Tiwari.* Palladium-catalyzed intramolecular cross-dehydrogenative coupling: synthesis of fused imidazo[1,2-a]pyrimidines and pyrazolo[1,5-a]pyrimidines. ACS Omega, 2017, 2(1), 11–19. doi:10.1021/acsomega.6b00417.

S. Pal, D. Choudhary, M. Jainth, S. Kumar; R. Tiwari, A. K. Verma. Regio- and stereoselective tandem synthesis of oxazolo fused pyridoindoles and benzofurooxazolo pyridines from ortho-alkynylaldehydes. Journal of Organic Chemistry, 2016, 81(19), 9356-9371. doi: 10.1021/acs.joc.6b02062. PMID: 27626809. 

A. K. Danodia, R. K. Saunthwal, M. Patel, R. K. Tiwari, A. K. Verma. Pd-catalyzed one-pot sequential unsymmetrical cross-coupling reactions of aryl/heteroaryl 1,2-dihalides. Org Biomol Chem. 2016, 14(27), 6487-6496. doi: 10.1039/c6ob01049k. PMID: 27286137. 

S. Kumar, C. Cruz-Hernández, S. Pal, R. K. Saunthwal, M. Patel, R. K. Tiwari, E. Juaristi, and A. K. Verma. Tandem Approach to Benzothieno- and Benzofuropyridines from o‑Alkynyl Aldehydes via Silver-Catalyzed 6-endo-dig Ring Closure. Journal of Organic Chemistry, 2015, 80(21), 10548-10560. doi: 10.1021/acs.joc.5b01647. PMID: 26457366. 

S. K. R. Kotla, D. Choudhary, R. K. Tiwari, A. K. Verma. Rhodium(III)-catalyzed double C-H activation: A straightforward approach to fused imidazo[1,2-a]pyridines from internal alkynes. Tetrahedron Letters, 2015, 56(32), 4706-4710.

B. Ramos-Molina, A. N. Lick, A. N. Shirazi, D. Oh, R. Tiwari, N. S. El-Sayed, K. Parang, I. Lindberg. Cationic Cell-Penetrating Peptides Are Potent Furin Inhibitors. PloS one. 2015; 10(6):e0130417. 

R. K. Saunthwal, M. Patel, R. K. Tiwari, K. Parang and A. K. Verma. On water: catalyst-free chemoselective synthesis of highly functionalized tetrahydroquinazolines from 2-aminophenylacrylate. Green Chemistry, 2015, 17, 1434-1441.

A. K. Verma, M. Patel, M. Joshi, P. R. Likhar, R. K. Tiwari, and K. Parang. Base-Mediated Chemo-and Stereoselective Addition of 5-Aminoindole/Tryptamine and Histamines onto Alkynes. Journal of Organic Chemistry, 2014, 79(1), 172-186.

A. Kumar, V. K. Rao, R. Tiwari, B. S Chhikara, A.N. Shirazi and K.Parang. Copper triflate-mediated synthesis of 1,3,5-triarylpyrazoles in [bmim][PF6] ionic liquid and evaluation of their anticancer activities. RSC Advances, 2013, 3, 15396-15403.

A. N. Shirazi, R. K. Tiwari, B. Sullivan, K. McCaffrey, D. Mandal, and K. Parang. Surface Decorated Gold Nanoparticles by Linear and Cyclic Peptides as Molecular Transporters. Molecular Pharmaceutics, 2013, 10(8), 3137-3151.

K. Chand, A. N. Shirazi, P. Yadav, R. K. Tiwari, M. Kumari, K. Parang and S. K. Sharma. Synthesis, Antiproliferative and c-Src kinase Inhibitory Activities of Cinnamoyl-and Pyranochromen-2-one Derivatives. Canadian Journal of Chemistry, 2013, 91(8), 741-754.

A. K. Verma, S. K. R. Kotla, T. Aggarwal, S. Kumar, H. Nimesh, and R. K. Tiwari. Tandem Synthesis of Pyrroloacridones via [3 + 2] Alkyne Annulation/Ring-Opening with Concomitant Intramolecular Aldol Condensation. Journal of Organic Chemistry, 2013, 78(11), 5372-5384.

V. K. Rao, G. Shelke, R. Tiwari, K. Parang, and A. Kumar. A Simple and Efficient Synthesis of 2,3-Diarynaphthofurans using Sequential Hydroarylation/Heck Oxyarylation. Organic Letters, 2013, 15(9), 2190-2193.



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