Welcome to the Peptide Therapeutic Laboratory (Tiwari Lab). We are in the School of Pharmacy at Chapman University. The laboratory, run by principal investigator Dr. Rakesh Tiwari. Our laboratory is located on the second floor of the Harry and Diane Rinker Health Science Campus (9501, Jeronimo Road) Building. We acknowledge the generous support from Chapman University School of Pharmacy.
Our expertise is in the area of developing small molecules and peptides for therapeutic application. We are interested in developing peptide-drug conjugates (PDC) for various application. Research areas range from the development of new synthetic methods for small molecule and peptide synthesis including a preclinical screening of compounds.
Congratulations to Paul for defending his Masters Thesis!
Congratulations to Dr. Siva Reddy for his paper in Scientific Report.
TrkB-enhancer facilitates functional recovery after traumatic brain injury
https://www.nature.com/articles/s41598-017-11316-8
Congratulations to Dr. Shaban Darwish for his paper in Tetrahedron Letters.
Cyclic peptide conjugate of curcumin and doxorubicin as an anticancer agent.
Tetrahedron Letters, 2017 (Accepted in Press).DOI: 10.1016/j.tetlet.2017.10.065
Congratulations to the group member for new publications:
Shirazi, A.S.; Mozaffari, S.; Sherpa, R. T.; Tiwari, R.; Parang, K. Efficient intracellular delivery of cell impermeable cargo molecules by peptides containing tryptophan and histidine. Molecules (2018) 23, 1536; doi:10.3390/molecules23071536.
El-Sayed, N. S.; Miyake, T.; Shirazi, A. N.; Park, S. E.; Clark, J.; Buchholz, S.; Parang, K.; Tiwari, R. Design, synthesis, and evaluation of homochiral peptides containing arginine and histidine as Molecular Transporters. Molecules (2018) 23(7), 1590; doi.:10.3390/molecules23071590.
Great job in oral presentations by Tim and David.
Kristedja, T.; Tiwari, R. Hybrid Peptide for the Treatment of Ovarian Cancer. 99th Annual Meeting of the AAASPD in Pomona, California June 13, 2018.
Akinwale, A.; Yamaki, J.; Parang, K.; Tiwari, R. Amphipathic Fatty Acyl-Cyclic [W4R4K] Peptides as Antimicrobial Agents against Pathogenic Bacteria. 99th Annual Meeting of the AAASPD in Pomona, California June 13, 2018. (David (Ajayi) got second place in oral presentation)