Publications

Rahighi S, Iyer M, Oveisi H, Nasser S, Duong V. Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain. Under Review. BioRxiv. doi: 10.1101/2022.02.25.482043. Preprint.

Hameedi M A, Prates ET, Garvin MR, Mathews I, Kirtley Amos B, Demerdash O, Iyer M, Rahighi S, Kneller DW, Kovalevsky A, Irle S, Vuong VQ, Mitchell JC, Labbe A, Galanie S, Wakatsuki S, Jacobson D. Structural and functional characterization of NEMO cleavage by SARS-CoV-2 3CLpro. Under Review. BioRxiv. doi: 10.1101/2021.11.11.468228. Preprint.

Sanner MF, Zoghebi K, Hanna S, Mozaffari S, Rahighi S, Tiwari RK, Parang K. Cyclic peptides as protein kinase inhibitors: structure-activity relationship and molecular modeling. J Chem Inf Model. 2021 Jun 28;61(6):3015-3026. PMID: 34000187

Nam Y-W, Cui M, Orfali R, Viegas A, Nguyen M, Mohammed EHM, Zoghebi KA, Rahighi S, Parang K, Zhang M. Hydrophobic interaction between the HA helix and S4-S5 linker modulate apparent Ca2+ sensitivity of SK2 channels. Acta Physiol. 2020 Aug 31; e13552. PMID: 32726587.

Maculins T, Garcia-Pardo J, Skenderovic A, Gebel J, Putyrski M, Vorobyov A, Busse P, Varga G, Kuzikov M, Zaliani A, Rahighi S, Schaeffer V, Parnham MJ, Sidhu SS, Ernst A, Dotsch V, Akutsu M, Dikic I. Discovery of protein-protein interaction inhibitors by integrating protein engineering and chemical screening platforms. Cell Chem Biol. 2020 Jul 27; S2451-9456. PMID: 32726587.

Herhaus L, van den Bedem H, Tang S, Maslennikov I, Wakatsuki S, Dikic I, Rahighi S. Molecular Recognition of M1-Linked Ubiquitin Chains by Native and Phosphorylated UBAN Domains. J Mol Biol. 2019 Aug 9;431(17):3146-3156. PubMed PMID: 31247202.

Raub AG, Hwang S, Horikoshi N, Cunningham AD, Rahighi S, Wakatsuki S, Mochly-Rosen D. Small-Molecule Activators of Glucose-6-phosphate Dehydrogenase (G6PD) Bridging the Dimer Interface. ChemMedChem. 2019 Jul 17;14(14):1321-1324. PubMed PMID: 31183991.

Hwang S, Mruk K, Rahighi S, Raub AG, Chen CH, Dorn LE, Horikoshi N, Wakatsuki S, Chen JK, Mochly-Rosen D. Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator. Nat Commun. 2018 Oct 2;9(1):4045. PubMed PMID: 30279493.

Fennell LM, Rahighi S, Ikeda F. Linear ubiquitin chain-binding domains. FEBS J. 2018 Aug;285(15):2746-2761. PubMed PMID: 29679476.

Rahighi S, Braunstein I, Ternette N, Kessler B, Kawasaki M, Kato R, Matsui T, Weiss TM, Stanhill A, Wakatsuki S. Selective Binding of AIRAPL Tandem UIMs to Lys48-Linked Tri-Ubiquitin Chains. Structure. 2016 Mar 1;24(3):412-22. PubMed PMID: 26876100.

Fujita H, Rahighi S, Akita M, Kato R, Sasaki Y, Wakatsuki S, Iwai K. Mechanism underlying IκB kinase activation mediated by the linear ubiquitin chain assembly complex. Mol Cell Biol. 2014 Apr;34(7):1322-35. PubMed PMID: 24469399.

Tufar P, Rahighi S, Kraas FI, Kirchner DK, Löhr F, Henrich E, Köpke J, Dikic I, Güntert P, Marahiel MA, Dötsch V. Crystal structure of a PCP/Sfp complex reveals the structural basis for carrier protein posttranslational modification. Chem Biol. 2014 Apr 24;21(4):552-562. PubMed PMID: 24704508.

Rahighi S, Dikic I. Selectivity of the ubiquitin-binding modules. FEBS Lett. 2012 Aug 14;586(17):2705-10. PubMed PMID: 22569095.

Oveisi H, Rahighi S, Jiang X, Nemoto Y, Beitollahi A, Wakatsuki S, Yamauchi Y. Unusual antibacterial property of mesoporous titania films: drastic improvement by controlling surface area and crystallinity. Chem Asian J. 2010 Sep 3;5(9):1978-83. PubMed PMID: 20665652.

Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I. Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell. 2009 Mar 20;136(6):1098-109. PubMed PMID: 19303852.