{"id":278,"date":"2015-06-25T21:37:21","date_gmt":"2015-06-25T21:37:21","guid":{"rendered":"https:\/\/sites.chapman.edu\/kaur\/?page_id=4"},"modified":"2015-06-25T21:37:21","modified_gmt":"2015-06-25T21:37:21","slug":"cv","status":"publish","type":"page","link":"https:\/\/sites.chapman.edu\/kaur\/cv\/","title":{"rendered":"Research"},"content":{"rendered":"<p data-start=\"108\" data-end=\"504\">The <strong data-start=\"112\" data-end=\"171\">Biomimetics and Molecular Engineering Laboratory (BMEL)<\/strong> is dedicated to the study of biologically active peptides and the design and synthesis of their metabolically stable analogues. Peptides\u2014short chains of natural amino acids\u2014interact with biological receptors and proteins with high specificity. However, their therapeutic use is often limited by rapid degradation due to proteolysis.<\/p>\n<p data-start=\"506\" data-end=\"732\">To address this limitation, we apply the principles of <strong data-start=\"561\" data-end=\"580\">peptidomimetics<\/strong>, a field focused on developing synthetic analogues that retain the biological activity of natural peptides while offering enhanced metabolic stability.<\/p>\n<p data-start=\"734\" data-end=\"862\">Our research centers on <strong data-start=\"758\" data-end=\"830\">engineering peptides and peptidomimetics for biomedical applications<\/strong>. We focus on two primary areas:<\/p>\n<ul data-start=\"864\" data-end=\"1103\">\n<li data-start=\"864\" data-end=\"1019\">\n<p data-start=\"866\" data-end=\"1019\"><strong data-start=\"866\" data-end=\"892\">Targeted drug delivery<\/strong> to treat cancers (e.g., breast, ovarian, uterine, cervical, and melanoma) and neurodegenerative diseases such as Alzheimer\u2019s<\/p>\n<\/li>\n<li data-start=\"1020\" data-end=\"1103\">\n<p data-start=\"1022\" data-end=\"1103\"><strong data-start=\"1022\" data-end=\"1048\">Biomedical diagnostics<\/strong> for early detection of cancers and pathogenic bacteria<\/p>\n<\/li>\n<\/ul>\n<p data-start=\"1105\" data-end=\"1272\">These efforts contribute to our broader mission of developing innovative therapeutics and diagnostic tools for cancer, infectious diseases, and neurological disorders.<\/p>\n<p data-start=\"1274\" data-end=\"1420\"><strong data-start=\"1274\" data-end=\"1287\">Keywords:<\/strong> Medicinal Chemistry \u00b7 Targeted Drug Delivery \u00b7 Diagnostics \u00b7 Infectious Disease \u00b7 Breast Cancer \u00b7 Pathogenic Bacteria \u00b7 Bacteriocins<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Targeted Drug Delivery<\/strong><\/p>\n<ul>\n<li><strong>Breast Cancer Targeted Drug Delivery:\u00a0<\/strong> Our goal here is to engineer breast cancer targeting peptides and peptide-drug conjugates (PDCs) for increasing the therapeutic efficacy of current chemotherapeutic drugs.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_Cells-2.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-231 aligncenter\" src=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_Cells-2.jpg\" alt=\"\" width=\"453\" height=\"252\" srcset=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_Cells-2.jpg 1920w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_Cells-2-300x167.jpg 300w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_Cells-2-1024x569.jpg 1024w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_Cells-2-768x427.jpg 768w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_Cells-2-1536x854.jpg 1536w\" sizes=\"auto, (max-width: 453px) 100vw, 453px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>Delivery to Brain:<\/strong> Here we are developing brain penetrant peptidomimetic amylin receptor antagonists for the treatment of Alzheimer&#8217;s disease.<\/li>\n<\/ul>\n<p><a href=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_BBB-peptide.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-225 aligncenter\" src=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_BBB-peptide.jpg\" alt=\"\" width=\"385\" height=\"145\" srcset=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_BBB-peptide.jpg 1177w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_BBB-peptide-300x113.jpg 300w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_BBB-peptide-1024x386.jpg 1024w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_BBB-peptide-768x290.jpg 768w\" sizes=\"auto, (max-width: 385px) 100vw, 385px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Biomedical Diagnostics<\/strong><\/p>\n<ul>\n<li><strong>Circulating Tumor Cells (CTCs):<\/strong> We are exploring peptide-based platforms for real time detection of CTCs in blood samples from breast cancer patients.\u00a0 The goal of this project is to develop a blood test (liquid biopsy) for breast cancer detection.<\/li>\n<\/ul>\n<p style=\"text-align: left\"><a href=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_CTC-sensor.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-226 aligncenter\" src=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_CTC-sensor.jpg\" alt=\"\" width=\"433\" height=\"215\" srcset=\"https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_CTC-sensor.jpg 1518w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_CTC-sensor-300x149.jpg 300w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_CTC-sensor-1024x509.jpg 1024w, https:\/\/sites.chapman.edu\/kaur\/wp-content\/uploads\/sites\/21\/2021\/10\/Figure_CTC-sensor-768x382.jpg 768w\" sizes=\"auto, (max-width: 433px) 100vw, 433px\" \/><\/a><\/p>\n<ul>\n<li><strong><strong>Pathogenic Bacteria:\u00a0<\/strong><span style=\"font-weight: 400\">\u00a0Antimicrobial peptides produced by bacteria, known as bacteriocins, are being\u00a0engineered for peptide-based biosensor platforms\u00a0to detect pathogenic bacteria like\u00a0<\/span><em style=\"font-weight: 400\">Listeria monocytogenes<\/em><span style=\"font-weight: 400\">,\u00a0<\/span><em style=\"font-weight: 400\">E. coli<\/em><span style=\"font-weight: 400\">,\u00a0<\/span><em style=\"font-weight: 400\">Salmonella<\/em><span style=\"font-weight: 400\">, etc.\u00a0 We also study bacteriocins to develop novel antibiotics against pathogenic and resistant strains<\/span><\/strong>.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Biomimetics and Molecular Engineering Laboratory (BMEL) is dedicated to the study of biologically active peptides and the design and synthesis of their metabolically stable analogues. Peptides\u2014short chains of natural amino acids\u2014interact with biological receptors and proteins with high specificity. &hellip; <a href=\"https:\/\/sites.chapman.edu\/kaur\/cv\/\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":48,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-278","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sites.chapman.edu\/kaur\/wp-json\/wp\/v2\/pages\/278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sites.chapman.edu\/kaur\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sites.chapman.edu\/kaur\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sites.chapman.edu\/kaur\/wp-json\/wp\/v2\/users\/48"}],"replies":[{"embeddable":true,"href":"https:\/\/sites.chapman.edu\/kaur\/wp-json\/wp\/v2\/comments?post=278"}],"version-history":[{"count":0,"href":"https:\/\/sites.chapman.edu\/kaur\/wp-json\/wp\/v2\/pages\/278\/revisions"}],"wp:attachment":[{"href":"https:\/\/sites.chapman.edu\/kaur\/wp-json\/wp\/v2\/media?parent=278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}