SELECTED RECENT PUBLICATIONS
View the full list of publications by the Ibba Lab here: Google Scholar
Steiner RE, Ibba M. (2019) Regulation of tRNA-dependent translational quality control. IUBMB Life.
Steiner RE, Kyle AM, Ibba M (2019) Oxidation of phenylalanyl-tRNA synthetase positively regulates translational quality control. PNAS. 116, 10058-10063
Tollerson II R, Witzky A, Ibba M (2018) Elongation factor P is required to maintain proteome homeostasis at high growth rate. PNAS. 115, 11072-11077.
Sahai KS, Steiner RE, Au MG, Graham JM, Salamon N, Ibba M, Pierson TM (2018) FARS2 mutations presenting with pure spastic paraplegia and lesions of the dentate nuclei. Ann Clin Transl Neurol. 5, 1128-1133.
Steiner RE, Ibba M (2018) Bridging the gap between tRNA modifications and the respiratory chain. Biochem. 57, 2565-2566.
Witzky A, Hummels KR, Tollerson R II, Rajkovic A, Jones LA, Kearns DB, Ibba M (2018) EF-P post-translational modification has variable impact on polyproline translation in Bacillus subtilis. mBio. 9, e00306-18.
Mohler K, Mann R, Kyle A, Reynolds N, Ibba M (2018) Aminoacyl-tRNA quality control is required for efficient activation of the TOR pathway regulator Gln3p. RNA Biol. 15, 594-603.
Kelly P, Ibba M (2017) Aminoacyl-tRNA quality control provides a speedy solution to discriminate right from wrong. J Mol Biol. 5, 17-19.
Tollerson R II, Witzky A, Ibba M (2017) Elongation factor P interactions with the ribosome are independent of pausing. mBio. 8, e01056-17.
Hummels KR, Witzky A, Rajkovic A, Tollerson R 2nd, Jones LA, Ibba M, Kearns DB (2017) Carbonyl reduction by YmfI in Bacillus subtilis prevents accumulation of an inhibitory EF-P modification state. Mol Microbiol. 106, 236-251.
Mohler K, Mann R, Bulwinkle TJ, Hopkins K, Hwang L, Reynolds NM, Gassaway B, Aerni HR, RinehartJ, Polymenis M, Faull K, Ibba M (2017) Editing of misaminoacylated tRNA controls the sensitivity of amino acid stress responses in Saccharomyces cerevisiae. Nucelic Acids Res. 45, 3985-3996.
Mohler K, Aerni HR, Gassaway B, Ling J, Ibba M, Rinehart J (2017) MS-READ: Quantitative measurement of amino acid incorporation. Biochim Biophys Acta. S0304-4165, 30033-8.
Mohler K, Mann R, Ibba M (2017) Isoacceptor specific characterization of tRNA aminoacylation and misacylation in vivo. Methods. 113, 127-131.
Elgamal S, Artsimovich I, Ibba M (2016) Maintenance of transcription-translation coupling by elongation factor P. mBio. 7, e01373-16.
Moghal A, Hwang L, Faull K, Ibba M (2016) Multiple quality control pathways limit non-protein amino acid use by yeast cytoplasmic phenylalanyl-tRNA syntheses. J. Biol. Chem. 291, 15796-805.
Katz A, Elgamal S, Rajkovic A, Ibba M (2016). Non-canonical roles of tRNAs and tRNA mimics in bacterial cell biology. Mol. Microbiol. 101, 545-58.
Rajkovic A, Hummels KR, Witzky A, Erickson S, Gafken PR, Whitelegge JP, Faull KF, Kearns DB, Ibba M (2016). Translation control of swarming proficiency in Bacillus subitlis by 5-Aminopentanolylated Elongation Factor P. J. Biol. Chem. 291, 10976-85.
Bullwinkle T and Ibba M (2016) Translation quality control is critical for bacterial responses to amino acid stress. Proc. Natl. Acad. Sci. USA. 113, 2252-7.
Rajkovic A, Erickson S, Witzky A, Branson OE, Seo J, Gafken PR, Frietas MA, Whitelegge JP, Faull KF, Navarre W, Darwin AJ and Ibba M. (2015) Cyclic rhamnosylated elongation factor P establishes antibiotic resistance in Pseudomonas aeruginosa. mBio. 6, e00823-15.
Rajkovic A, Witzky A, Navarre W, Darwin AJ and Ibba M (2015) Elongation factor-P at the crossroads of the host-endosymbiont interface. Microbial Cell. 2, 360-362.
Shepherd J and Ibba M (2015) Bacterial transfer RNAs. FEMS Microbiol Rev. 39, 280-300.
Shepherd J and Ibba M (2015) Bacterial transfer RNAs. FEMS Microbiol Rev. 39, 280-300.
Ibba M. (2015) Transfer RNA comes of age. RNA 21, 648-649.
Williams-Wagner RN, Grundy FJ, Raina M, Ibba M and Henkin TM (2015) The Bacillus subtilistyrZ gene encodes a highly selective tyrosyl-tRNA synthetase and is regulated by a MarR regulator and T box riboswitch. J. Bacteriol. 197, 1624-1631.
Elgamal S, Katz A, Hersch SJ, Newsom D, White P, Navarre WW and Ibba, M. (2014) EF-P dependent pauses integrate proximal and distal signals during translation. PLoS Genetics 10 e1004553.PDF
Bullwinkle TJ, Reynolds NM, Raina M, Moghal A, Matsa E, Rajkovic A., Kayadibi H, Fazlollahi F, Ryan C, Howitz N, Faull K, Lazazzera BA and Ibba M. (2014) Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code. eLife e02501.PDF
Bullwinkle TJ, Lazazzera BA and Ibba M. (2014) Quality control and infiltration of translation by amino acids outside of the genetic code. Annu. Rev. Genet. 48, 149-166. PDF
Hersch SJ, Elgamal S, Katz A, Ibba M and Navarre WW (2014) Translation initiation rate determines the impact of ribosome stalling on bacterial protein synthesis. J. Biol. Chem. 289, 28160-28171.PDF
Shepherd J and Ibba M (2014) Relaxed substrate specificity leads to extensive tRNA mischarging by Streptococcus pneumoniae class I and class II aminoacyl-tRNA synthetases. mBio 5, e01656-14PDF
Raina M and Ibba M (2014) tRNAs as regulators of biological processes. Front. Genet. 5 171.PDF
Raina M, Moghal A, Kano A, Jerums M, Schnier PD, Luo S, Deshpande R, Bondarenko PV, Lin H and Ibba M. (2014) Reduced amino acid specificity of mammalian tyrosyl-tRNA synthetase is associated with elevated mistranslation of Tyr codons. J. Biol. Chem. 289, 17780-17790.PDF
Katz A, Solden L, Zou SB, Navarre WW and Ibba M. (2014) Molecular evolution of protein-RNA mimicry as a mechanism for translational control. Nucleic Acids Res. 42, 3261-3271.PDF
OTHER RELEVANT PUBLICATIONS
Bullwinkle TJ, Zou SB, Rajkovic A, Hersch SJ, Elgamal S, Robinson N, Smil D, Bolshan Y, Navarre WW and Ibba M. (2013) (R)-β-lysine modified elongation factor P functions in translation elongation. J. Biol. Chem 288, 4416-4423.PDF
Yadavalli SS and Ibba M. (2013) Selection of tRNA charging quality control mechanisms that increase mistranslation of the genetic code. Nucleic Acids Res. 41, 1104-1112.PDF
Shepherd J and Ibba M (2013) Lipid II-independent trans editing of mischarged tRNAs by the penicillin resistance factor MurM. J. Biol. Chem. 288, 25915-25923.PDF
Elo, JM, Yadavalli SS, Euro L, Isohanni P, Götz A, Carroll C, Valanne L, Alkuraya FS, Uusimaa J, Paetau A, Caruso EM, Pihko H, Ibba M, Tyynismaa H & Suomalainen A (2012) Mitochondrial phenylalanyl-tRNA synthetase mutations underlie fatal infantile Alpers encephalopathy. Hum. Mol. Genet. 21, 4521-4529.
Roy H, Zou SB, Bullwinkle TJ, Wolfe BS, Gilreath MS, Forsyth CJ, Navarre WW & Ibba M (2011) The tRNA synthetase paralog PoxA modifies elongation factor-P with (R)-β-lysine. Nat. Chem. Biol. 7, 667-669. Nature Research Highlight. OSU news.
Reynolds NM, Lazazzera BA & Ibba M. (2010) Cellular mechanisms that control mistranslation. Nat Rev Microbiol 8, 849-856.
Weygand-Durasevic I & Ibba M. (2010) New roles for codon usage. Science 329, 1473-1474.
Roy H & Ibba M. (2010) Bridging the gap between ribosomal and non-ribosomal protein synthesis. Proc Natl Acad Sci USA 107, 14517-14518.
Navarre WW, Zou S, Roy H, Xie JL, Savchenko A, Singer A, Evdokimova E, Prost LR, Kumar R, Ibba M & Fang FC. (2010) PoxA, YjeK and elongation factor P coordinately modulate virulence and drug resistance in Salmonella enterica. Mol Cell 39, 209-221.
Reynolds NM, Ling J, Roy H, Banerjee R, Repasky SE, Hamel P & Ibba M. (2010) Cell-specific differences in the requirements for translational quality control. Proc Natl Acad Sci USA 107, 4063-4068..
Ling J, So BR, Yadavalli SS, Roy H, Shoji S, Fredrick K, Musier-Forsyth K & Ibba M. (2009) Resampling and editing of mischarged tRNA prior to translation elongation. Mol Cell 33, 654-660.
Roy H & Ibba M. (2008) RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors. Proc Natl Acad Sci USA 105, 4667-4672.
Ling J, Roy H, Qin D, Rubio MA, Alfonzo JD, Fredrick K & Ibba M. (2007) Pathogenic mechanism of a human mitochondrial tRNAPhe mutation associated with MERRF syndrome. Proc Natl Acad Sci USA 104, 15299-15304.
Ling J, Roy H & Ibba M. (2007) Mechanism of tRNA-dependent editing in translational quality control. Proc Natl Acad Sci USA 104, 72-77.
Sauerwald A, Zhu W, Major TA, Roy H, Palioura S, Jahn D, Whitman W, Yates JR 3rd, Ibba M & Söll D. (2005) RNA-dependent cysteine biosynthesis in archaea. Science 307, 1969-1972.
Roy H, Ling J, Irnov and Ibba M. (2004) Post-transfer editing in vitro and in vivo by the beta-subunit of phenylalanyl-tRNA synthetase. EMBO J. 23, 4639-4648.
Jester B, Levengood J, Roy H, Ibba M & Devine K. (2003) Non-orthologous replacement of lysyl-tRNA synthetase prevents addition of lysine analogs to the genetic code. Proc Natl Acad Sci USA 100, 14351-14356.