Stress responsive RNP granules in ovaries

Ovaries are filled with Ribonucleoprotein (RNP) granules that tightly regulate processing, translation, transport, and degradation of mRNAs during oocyte development. Ovaries are also capable of forming stress granules, transient RNP granules that form in response to acute environmental stressors (e.g. heatshock, hypoxia). The Glineburg lab is interested in understanding what mediates stress granule formation in ovaries and how do stress granules interact with other established RNPs in this context.

Stress response proteins in neuronal development

The Glineburg lab is exploring the role of stress granule proteins in neuronal differentiation, and stem cell regulation.

Integrated stress response attenuation to rescue neurodegeneration models

The Glineburg lab is interested in understanding how integrated stress response pathway regulators influence neurodegeneration. We are particularly interested in how these regulators modulate protein aggregation, and neuronal death.