Publications

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Publications:  [PubMed]

  1. Alexander AK, Elshahawi SI. Promiscuous enzymes for residue-specific peptide and protein late-stage functionalization. ChemBioChem. 2023 In press [Link]
  2. Aoun AR, Mupparapu N, Nguyen DN, Kim TH, Nguyen CM, Pan Z, Elshahawi SI. Structure-guided mutagenesis reveals the catalytic residue that controls the regiospecificity of C6-indole prenyltransferases. ChemCatChem. 2023 June 9; 15 (11): e202300423. [Link]
  3. Mupparapu N, Brewster L, Ostrom KF, Elshahawi SI. Late-stage chemoenzymatic installation of hydroxy-bearing allyl moiety on the indole ring of tryptophan-containing peptides. Chem Eur J. 2022 Apr 6;28(20):e202104614. PMID: 35178791. [Pubmed]
  4. Clinger JA, Zhang Y, Liu Y, Miller MD, Hall RE, Van Lanen SG, Phillips GN Jr., Thorson JS, Elshahawi SI. Structure and function of a dual reductase-dehydratase enzyme system involved in p-terphenyl biosynthesis. ACS Chem Biol. 2021 Dec 17;16(12):2816-2824. PMID: 34763417. [Pubmed]
  5. Mupparapu N, Lin Y-HC, Kim TH, Elshahawi SI. Regiospecific synthesis of calcium-independent daptomycin antibiotics using a chemoenzymatic method. Chem Eur J. 2021;27(12):4176-4182. PMID: 33244806, doi: 10.1002/chem.202005100. [Pubmed]
  6. Wang X, Elshahawi SI, Ponomareva LV, Ye Q, Liu Y, Copley GC, Hower JC, Hatcher BE, Kharel MK, Van Lanen SG, She Q-B, Voss SR, Thorson JS, Shaaban KA. Structure determination, functional characterization and biosynthetic implications of nybomycin metabolites from a mining reclamation site-associated J Nat Prod. 2019 82(12):3469-3476. [Pubmed]
  7. Wang X, Abbas M, Zhang Y, Elshahawi SI, Ponomareva LV, Cui Z, Van Lanen SG, Sajid I, Voss SR, Shaaban KA, Thorson JS. Baraphenazines A-G, divergent fused phenazine-based metabolites from a Himalayan Streptomyces. J Nat Prod. 2019, 82(6):1686-1693. [Pubmed]
  8. Abbas M, Elshahawi SI, Wang X, Ponomareva LV, Sajid I, Shaaban KA, Thorson JS. Puromycins B–E, naturally occurring amino-nucleosides produced by the Himalayan isolate Streptomyces PU-14G. J. Nat. Prod., 2018, 81(11): 2560–2566. [Pubmed]
  9. Wang X, Elshahawi SI, Cai W, Zhang Y, Ponomareva LV, Chen X, Copley GC, Hower JC, Zhan CG, Parkin S, Rohr J, Van Lanen SG, Shaaban KA, Thorson JS. Bi- and tetracyclic spirotetronates from the coal mine fire isolate Streptomyces LC-6-2. J Nat Prod. 2017, 80(4):1141-1149. [Pubmed]
  10. Elshahawi SI, Cao C, Shaaban KA, Ponomareva LV, Subramanian T, Farman ML, Spielmann HP, Phillips GN Jr., Thorson JS, Singh S. Structure and specificity of a permissive bacterial C-prenyltransferase, Nat Chem Biol. 2017, 13(4):366-368. [Pubmed]
  11. Wang X, Zhang Y, Ponomareva LV, Qiu Q, Woodcock R, Elshahawi SI, Chen X, Zhou Z, Hatcher BE, Hower JC, Zhan CG, Parkin S, Kharel MK, Voss SR, Shaaban KA, Thorson JS. Mccrearamycins A-D, geldanamycin-derived cyclopentenone macrolactams from an Eastern Kentucky abandoned coal mine microbe. Angew Chem Int Ed Engl. 2017, 56(11):2994-2998. [Pubmed]
  12. Zhang J, Hughes RR, Saunders MA, Elshahawi SI, Ponomareva LV, Zhang Y, Winchester SR, Scott SA, Sunkara M, Morris AJ, Prendergast MA, Shaaban KA, Thorson JS. Identification of neuroprotective spoxazomicin and oxachelin glycosides via chemoenzymatic glycosyl-scanning. J Nat Prod. 2017, 80(1):12-18. [Pubmed]
  13. Shaaban KA, Saunders MA, Zhang Y, Tran T, Elshahawi SI, Ponomareva LV, Wang X, Zhang J, Copley GC, Sunkara M, Kharel MK, Morris AJ, Hower JC, Tremblay MS, Prendergast MA, Thorson JS. Spoxazomicin D and oxachelin C, potent neuroprotective carboxamides from the Appalachian coal fire-associated isolate Streptomyces RM-14-6. J Nat Prod. 2017, 80(1):2-11. [Pubmed]
  14. Wenlong C, Wang X, Elshahawi SI, Ponomareva LV, Liu X, McErlean M, Cui Z, Arlinghaus A, Thorson JS, Van Lanen SG. Antibacterial and cytotoxic actinomycins Y6-Y9 from Streptomyces strain Gö-GS12. J Nat Prod. 2016, 79(10):2731-2739. [Pubmed]
  15. Shaaban KA, Elshahawi SI, Wang X, Horn J, Kharel MK, Leggas M, Thorson JS. Cytotoxic indolocarbazoles from Actinomadura melliaura ATCC 39691. J Nat Prod. 2015, 78(7):1723-1729. [Pubmed]
  16. Wang X, Reynolds AR, Elshahawi SI, Shaaban KA, Ponomareva LV, Saunders MA, Elgumati IS, Zhang Y, Copley GC, Hower JC, Sunkara M, Morris AJ, Kharel MK, Van Lanen SG, Prendergast MA, Thorson JS. Terfestatins B and C, new p-terphenyl glycosides produced by Streptomyces RM-5-8. Org Lett. 2015, 17(11):2796-2799. [Pubmed]
  17. Elshahawi SI*, Shaaban KA*, Kharel MK,Thorson JS. A comprehensive review of glycosylated bacterial natural products.  Chemical Society Reviews. 2015, 44(21):7591-7697. [Pubmed]
  18. Elshahawi SI, Ramelot TA, Seetharaman J, Chen J, Singh S, Yang Y, Pederson K, Kharel MK, Xiao R, Lew S, Yennamalli RM, Miller MD, Wang F, Tong L, Montelione GT, Kennedy MA, Bingman CA, Zhu H, Phillips GN Jr, Thorson JS. Structure-guided functional characterization of enediyne self-sacrifice resistance proteins, CalU16 and CalU19. ACS Chem Biol. 2014, 9(10):2347-2358. [Pubmed]
  19. Wang X, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. Mullinamides A and B, new cyclopeptides produced by the Ruth Mullins coal mine fire isolate Streptomyces RM-27-46. J. Antibiot. 2014, 67(8):571-575. [Pubmed]
  20. Wang X, Elshahawi SI, Shaaban KA, Fang L, Ponomareva LV, Zhang Y, Copley GC, Hower JC, Zhan C-G, Kharel MK, Thorson JS. Ruthmycin, a new tetracyclic polyketide from Streptomyces RM-4-15. Org. Lett. 2014, 16(2):456-459. [Pubmed]
  21. Shaaban KA, Singh S, Elshahawi SI, Wang X, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. The native production of the sesquiterpene isopterocarpolone by Streptomyces RM-14-6. Nat Prod Res. 2014, 28(5):337-339. [Pubmed]
  22. Shaaban KA, Singh S, Elshahawi SI, Wang X, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. Venturicidin C, a new 20-membered macrolide produced by Streptomyces TS-2-2. J. Antibiot. 2013, 67(3):223-230. [Pubmed]
  23. Shaaban KA, Wang X, Elshahawi SI, Ponomareva LV, Sunkara M, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. Herbimycins D-F, ansamycin analogues from Streptomyces RM-7-15. J Nat Prod. 2013, 76(9):1619-1626. [Pubmed]
  24. Wang X, Shaaban KA, Elshahawi SI, Ponomareva LV, Sunkara M, Zhang Y, Copley GC, Hower JC, Morris AJ, Kharel MK, Thorson JS. Frenolicins C-G, pyranonaphthoquinones from Streptomyces RM-4-15. J Nat Prod. 2013, 76(8):1441-1447. [Pubmed]
  25. Elshahawi SI, Trindade-Silva AE, Hanora A, Han AW, Flores MS, Vizzoni V, Schrago CG, Soares CA, Concepcion GP, Distel DL, Schmidt EW, Haygood MG. Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills. Natl. Acad. Sci (PNAS). 2013, 110(4):E295-304. [Pubmed]
  26. Donia M , Fricke WF, Partensky F, Cox J, Elshahawi SI, White J, Phillippy A, Schatz M, Piel J, Haygood M, Ravel J, Schmidt EW. Complex microbiome underlying secondary and primary metabolism in the tunicate-Prochloron Proc. Natl. Acad. Sci (PNAS). 2011, 108(51):E1423-E1432. [Pubmed]
  27. Yang JC, Madupu R, Durkin AS, Ekborg NA, Pedamallu CS, Hostetler JB, Radune D, Toms BS, Henrissat B, Coutinho PM, Schwarz S, Field L, Trindade-Silva AE, Soares CA, Elshahawi S, Hanora A, Schmidt EW, Haygood MG, Posfai J, Benner J, Madinger C, Nove J, Anton B, Chaudhary K, Foster J, Holman A, Kumar S, Lessard PA, Luyten YA, Slatko B, Wood N, Wu B, Teplitski M, Mougous JD, Ward N, Eisen JA, Badger JH, Distel DL. The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms). PLoS One. 2009, 4(7):E6085. [Pubmed]

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